Spermacoce neoterminalis, commonly known as Everglades Key False Buttonweed, is a herbaceous perennial native to the southeastern United States. This species is a member of the Rubiaceae family, which also includes coffee and gardenia. Its significance lies in its role within its specific ecological niche, contributing to the biodiversity of its native habitats. The growth habit of Spermacoce neoterminalis is typically erect to spreading, forming a low-growing herbaceous plant. It generally reaches a height of about 30 to 60 centimeters. The stems are often quadrangular and can be somewhat woody at the base. Leaves are arranged oppositely along the stem, are lanceolate to ovate in shape, and measure approximately 2 to 5 centimeters in length. They are usually smooth or slightly hairy, with entire margins. The inflorescences are terminal or axillary clusters of small, inconspicuous flowers. Each flower possesses a tubular corolla, typically white or pale pink, with four lobes. The blooming period usually occurs during the warmer months, from late spring through summer. Following flowering, small, dry fruits develop, which are often capsules containing tiny seeds. Spermacoce neoterminalis is primarily found in the coastal regions of Florida, particularly in the Florida Keys and the Everglades. Its natural habitat includes sandy soils, pine flatwoods, coastal hammocks, and disturbed areas near the coast. It thrives in well-drained soils and prefers full sun to partial shade. While it is adapted to its native environment, cultivation outside its natural range is not widely documented, and it is generally considered a plant of specific ecological requirements. Ecologically, Everglades Key False Buttonweed serves as a food source and habitat for various native insects and small animals. Its role in the ecosystem is tied to the unique conditions of the South Florida coastal landscape. There is no established ornamental, agricultural, medicinal, culinary, or economic importance documented for this species. An interesting characteristic of Spermacoce neoterminalis is its adaptation to the sandy, nutrient-poor soils characteristic of its native coastal habitats. Like other members of the Spermacoce genus, it may have adaptations for survival in these challenging environments. The small, often overlooked flowers are typical of many species in the Rubiaceae family, relying on small pollinators or wind for dispersal. The plant's presence is an indicator of the specific ecological conditions found in the Florida Keys and the Everglades.